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. 2004 Jul 7;24(27):6144–6151. doi: 10.1523/JNEUROSCI.1090-04.2004

Figure 6.

Figure 6.

Fcγ receptor expression on microglia is increased after 1 month of anti-Aβ antibody treatment and remains increased after 2 months of treatment. A-D, Fcγ receptor immunohistochemistry in the hippocampus of APP transgenic mice receiving the control antibody for 3 months (A), the anti-Aβ antibody for 1 month (B), the anti-Aβ antibody for 2 months (C), or the anti-Aβ antibody for 3 months (D). Magnification, 100×. Scale bar, 50 μm. E, Quantification of the percent area occupied by the Fcγ receptor-positive stain in the frontal cortex and hippocampus. The single bar shows the value for APP transgenic mice receiving the control antibody for 3 months. The line shows the values for APP transgenic mice receiving the anti-Aβ antibody for 1, 2, and 3 months. *p < 0.05. DG, Dentate gyrus; F, hippocampal fissure.