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. 2004 Jul 7;24(27):6144–6151. doi: 10.1523/JNEUROSCI.1090-04.2004

Figure 7.

Figure 7.

CD45 expression on microglia is increased after 2 months of anti-Aβ antibody treatment. A-D, CD45 immunohistochemistry in the hippocampus of APP transgenic mice receiving the control antibody for 3 months (A), the anti-Aβ antibody for 1 month (B), the anti-Aβ antibody for 2 months (C), or the anti-Aβ antibody for 3 months (D). F, Hippocampal fissure; DG, dentate gyrus. Magnification, 100×. Scale bar, 50 μm. E-H, Magnified images of non-amyloid-containing areas from A-D, showing CD45 immunohistochemistry in the hippocampus of APP transgenic mice receiving the control antibody for 3 months (E), the anti-Aβ antibody for 1 month (F), the anti-Aβ antibody for 2 months (G), or the anti-Aβ antibody for 3 months (H). I, Quantification of the percent area occupied by the CD45-positive stain in the frontal cortex and hippocampus. The singlebar shows the value for APP transgenic mice receiving the control antibody for 3 months. The line shows the values for APP transgenic mice receiving the anti-Aβ antibody for 1, 2, and 3 months. *p < 0.05.