Figure 4.

The number of proliferating cells in the SVZ and dorsolateral corner decreases with age. There are fewer proliferating cells (BrdU labeled) seen in 2-month-old (2M) SVZs than in those of 24-month-old (24M) SVZs. Similarly, the numbers of neuronal progenitors immunoreactive for PSA-NCAM and MASH1 in the dorsolateral corner of the SVZ, seen in 2-month-old mice, are significantly reduced in their 24-month-old counterparts. The corresponding quantitative data are in Table 2. Scale bars: (in bottom left) top left, bottom left, 100 μm; (in bottom right) middle and right, 50 μm.