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. 2004 Sep 22;24(38):8193–8197. doi: 10.1523/JNEUROSCI.1657-04.2004

Figure 1.

Figure 1.

Chronic morphine sensitizes LC neurons to CRF. A, Traces representing LC discharge rate in saline-treated and 7 d morphine rats before and after 3 ng of CRF (bar). Baseline rates were comparable. B, Mean effect of CRF (3 ng) as a function of time in vehicle (solid circles; n = 5), 1 d morphine (open triangles; n = 6), and 7 d morphine (open circles; n = 7) rats. CRF was administered at arrow (Time = 0). There was an effect of treatment (F(2,15) = 4.75; p < 0.05), time (F(18,270) =4.3;p<0.0001), and a time-treatment interaction (F(36,270) =3.22;p < 0.0001). C, CRF dose-response curves in vehicle (solid circles) or 7 d morphine (open circles) rats. Points represent the mean maximum effect produced by CRF at any time after injection (n = 5-7 determinations). *p < 0.05, Student's t test for independent samples. Bars in B and C indicate SEM.