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. 2004 Sep 22;24(38):8232–8236. doi: 10.1523/JNEUROSCI.2695-04.2004

Figure 1.

Figure 1.

The I848T and L858H mutations of hNav1.7 alter activation and deactivation. A, Current traces recorded from representative HEK293 cells expressing either wild-type hNav1.7 or mutant channels, I848T or L858H. Cells were held at -100 mV, and currents were elicited with 50 msec test pulses to potentials ranging from -80 to 40 mV. B, Normalized peak current-voltage relationship for wild-type (filled squares; n = 29), I848T (open circles; n = 27), and L858H (open triangles; n = 27) channels. C, Representative tail currents of WT, I848T, and L858H channels. Cells were held at -100 mV and depolarized to -20 mV for 0.5 msec, followed by a repolarization to -50 mV to elicit tail currents. D, Time constants for tail current deactivation at repolarization potentials ranging from -40 to -100 mV for wild-type (filled squares; n = 7), I848T (open circles; n = 7), and L858H (open triangles; n = 7) hNav1.7 channels. Time constants were obtained with single exponential fits to the deactivation phase of the currents. Error bars represent SE.