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. 2004 Apr 7;24(14):3592–3599. doi: 10.1523/JNEUROSCI.5167-03.2004

Figure 6.

Figure 6.

Aβ42 oligomerization within dystrophic processes of human AD brain. A, Aβ42 oligomers (empty arrows) are observed in degenerating neurites and are not associated with more normal-appearing neuropil (middle area of image). A darkened, abnormal-appearing postsynaptic profile is also observed (plus sign). m, Mitochondrion. Scale bar, 1μm. B, A higher-power image of a degenerating neurite in A (A, right empty arrow). Aβ42 oligomers (empty arrows) are associated with a tubulovesicular-like organelle (empty arrowhead) and granular fibril-like electron-dense material (filled arrowheads). Isolated Aβ42 oligomers localize to the membrane of presynaptic profile (left empty arrow) associated with a darkened, degenerating-appearing postsynaptic profile (plus sign). m, Mitochondrion. C, Aggregated Aβ42 oligomers (empty arrow) appear associated with a tubulovesicular-like organelle (empty arrowhead) in a postsynaptic compartment with an active zone (thin arrow). m, Mitochondrion. Scale bar, 300 nm. D, M16 Aβ42 oligomers aggregate on tubular-like membranous structures within a disrupted, swollen dendrite containing abnormal dark profiles (asterisks), consistent with degeneration; no normal organelles can be found in this postsynaptic profile. Presynaptic profiles are seen on the right (arrow) and left (arrowhead) corners of the image; the left one is darkened, indicative of degeneration. Scale bar, 250 nm.