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. 2004 Apr 7;24(14):3471–3479. doi: 10.1523/JNEUROSCI.5740-03.2004

Figure 3.

Figure 3.

Five day priming of the amygdala with Ucn requires NMDA receptor activation. A, Coadministration of the active form of the NMDA receptor antagonist dl-AP-5 together with Ucn (6 fmol) for 5 d blocks the priming response observed. B, Coadministration of dl-AP-5 and Ucn (6 fmol) on day 5 priming only did not block the priming response. C, Administration of the CaMKII inhibitor KN-62, (1 fmol) administered 30 min before Ucn (6 fmol) daily for 5 d, blocked the induction of the priming response (n = 9). D, If given during the maintenance phase (i.e., on day 5 priming only), KN-62 no longer has an effect (t = 5.487; p = 0.0054; n = 5). Asterisk, Significantly different from baseline.