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. 2004 Apr 7;24(14):3600–3609. doi: 10.1523/JNEUROSCI.1134-03.2004

Figure 3.

Figure 3.

Site-specific ITM has a unique molecular mechanism. A, Mean ± SEM normalized duration of T-SW over time in preparations treated with or without the protein synthesis inhibitor emetine (100 μm) throughout the experiment (n = 6 per group). B, Mean ± SEM normalized duration of T-SW over time in preparations treated with the PKA inhibitor KT5720 (10 μm) or vehicle (1% DMSO) for 30 min before and during training with a single shock to the test site (n = 5 per group). KT5720–vehicle was added to the ring ganglia subchamber after completion of the pretests and was washed out immediately after training. C, Mean ± SEM normalized duration of T-SW over time in preparations treated with 10 μm KT5720 (n = 6) or vehicle (n = 7) beginning 30 min after training with a single shock to the test site. KT5720–vehicle (KT/Vehicle) was washed out immediately after the 75 min post-test. Drug–vehicle application is indicated by shading. Pre1–Pre3, Pretests 1–3.