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. 2004 Aug 18;24(33):7353–7365. doi: 10.1523/JNEUROSCI.1850-04.2004

Figure 4.

Figure 4.

Coadministration of an IL-1ra with an intrathecal infusion of morphine attenuates the development of exaggerated pain sensitivity after morphine. Top, Animals given five once-daily infusions of morphine (10 μg) developed thermal hyperalgesia in the tail flick test using an infrared light source when tested 24 hr after the last infusion of morphine. Coadministration of IL-1ra (100 μg) reduced the hyperalgesic effect of morphine. Bottom, Animals given five once-daily infusions of morphine (10 μg) developed tactile allodynia in the von Frey test when tested 24 hr after the last infusion of morphine. Coadministration of IL-1ra (100 μg) reduced the allodynic effect of morphine.