Figure 3.

The β₁-adrenoceptor antagonist atenolol (1.25 μg in 0.5 μl) administered into the hippocampus 60 min before retention testing blocked the impairing effects induced by coadministration of the GR agonist RU 28362 (15 ng) on probe trial retention performance in a water maze. A, Time spent in the training (T) and opposite (O) quadrants (mean + SEM) in seconds during the 60 sec probe trial. B, Latencies (mean + SEM) in seconds to cross the platform location. ^*p < 0.05, ^**p < 0.01 compared with the corresponding vehicle group; ^♦p < 0.05, ^♦♦p < 0.01 compared with the RU 28362 group; ^**p < 0.01 compared with the training quadrant (n = 11-13 per group).