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A, Hydrophobicity plot of Hm-Inx1 and Hm-Inx2 derived using the DAS algorithm (Cserzo et al., 1997). Each spike on the plot that crosses the strict threshold indicates a predicted transmembrane domain. B, The predicted topology of an innexin protein. Innexins are thought to have four transmembrane domains (numbered cylinders) with intracellular N and C termini. The two extracellular loops each contain two completely conserved cysteine residues (C).
