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. 2004 Jan 28;24(4):828–835. doi: 10.1523/JNEUROSCI.3831-03.2004

Figure 3.

Figure 3.

Striatal DA, DOPAC, and HVA levels in wild-type or mGlu5 receptor knock-out mice treated with high doses of MPTP ± MPEP, as described in Figures 1 and 2. Values are mean ± SEM of determinations from six mice. *p<0.05 (one-way ANOVA plus Fisher's PLSD) versus the respective control mice treated with saline. #p < 0.05 (one-way ANOVA plus Fisher's PLSD) versus wild-type mice treated with MPTP and saline. A representative immunoblot of mGlu5 receptors in the cerebral cortex of wild-type and knock-out mice is also shown. Thirty micrograms of proteins was loaded per lane. The top band at ∼145 kDa corresponding to the mGlu5 receptor monomer is visible only in the cortex of the wild-type mouse.