Table 2.
Differential expression derived from the microarrays
|
|
BLAST |
|
CA3 subfield |
|
Dentate gyrus |
|
|---|---|---|---|---|---|---|
| Clone accession number |
Gene name |
Accession number |
aC3+/T+ |
aC3+/T- |
aC3+/T+ |
aC3+/T- |
| AA086732 | Nuclear inhibitor of protein phosphatase-1 | AL020997 | 2.70 | |||
| W91158 | p53-regulated PA26 nuclear protein | NM_014454 | 2.45 | |||
| AA161816 | Apoptosis inhibitory protein 5 | XM_123850 | 2.21 | |||
| W08616 | EST | AF024647 | 2.17 | |||
| W76728 | EST | XM_124397 | 1.76 | |||
| AI893666 | Shroom | XM_124564 | 1.75 | |||
| AA217294 | EST | NM_058962 | 1.67 | |||
| AI385776 | Calpain 6 | XM_136093 | 1.66 | |||
| AA270270 | Estrogen-related receptor a pseudogene | AL359457 | 1.62 | |||
| AI591874 | EST | AF029875 | 1.61 | |||
| W08432 | Brain protein 44-like protein | AF181116 | 1.59 | |||
| AA397275 | F-box and leucine-rich repeat protein 10 | AF176524 | 1.57 | |||
| AA396001 | EST | AF456412 | 1.56 | |||
| AA543916 | Unc-51 serine/threonin kinase | AF072370 | 1.55 | |||
| AI450438 | EST | AL591074 | 1.54 | |||
| AI595497 | Adult male hippocampus cDNA | AK013461 | 1.54 | |||
| AA276492 | S-adenosylmethionine decarboxylase | AB025024 | 1.50 | |||
| AA241132 | Coatomer protein complex, subunit g1 | NM_017477 | -1.91 | |||
| W13905 | Fibrinogen/angiopoietin-related protein | BC006611 | -1.80 | |||
| AA177260 | Progestin-induced protein | NM_015902 | -1.75 | |||
| AA009187 | 60S acidic ribosomal protein | AF173378 | -1.72 | |||
| AA200282 | Tristetraproline | M57422 | -1.71 | |||
| AI386396 | Vacuolar protein sorting protein 4a | NM_126165 | -1.67 | |||
| AA240082 | Neuronal development-associated protein 7 | AF361435 | -1.64 | |||
| AA207759 | Cleavage stimulation factor | NM 001324 | -1.63 | |||
| W53913 | Transcription factor GATA-4 | AB075549 | -1.60 | |||
| AA097901 | Asparaginase like | AF329099 | -1.60 | |||
| AA272747 | Nuclear factor, erythroid-derived 2 | XM_128255 | -1.55 | |||
| AA499756 | EST | XM_003245 | -1.54 | |||
| W59380 | EST | U80078 | -1.53 | |||
| AA024100 | RaIBP1-associated Eps domain-containing protein | NM_009048 | -1.52 | |||
| AA003646 | Signal recognition particle 68 kDa protein | XM_126768 | -1.51 | |||
| AI386256 | Protein kinase, DNA activated, catalytic polypeptide | XM_148184 | 4.76 | |||
| AA065728 | EST | AF179588 | 2.43 | |||
| AI466677 | Lymphocyte antigen 6 complex | XM_133803 | 2.30 | |||
| AA144535 | EST | M81448 | 2.28 | |||
| AA237920 | EST | NM_015981 | 2.17 | |||
| W40590 | EST | NM_021684 | 2.10 | |||
| W16247 | Putative homology to T-cell g receptor | XM_125725 | 1.79 | |||
| W36541 | Connective tissue growth factor precursor | XM_122007 | 1.71 | |||
| W83271 | ATP-binding cassette, subfamily F | XM_131932 | 1.68 | |||
| AA061359 | Kruppel-like factor 15 | NM_023184 | 1.65 | |||
| AA387537 | ATP-dependent helicase (RNA helicase) | XM_126585 | 1.54 | |||
| AA108457 | Cytochrome P450 monooxygenase | XM_028050 | 1.51 | |||
| AA404092 | Archain 1 | XM_134811 | 1.50 | |||
| AA237828 | Protein S a | XM_148185 | -2.94 | |||
| AA250659 | EST | XM_145607 | -2.86 | |||
| AA271147 | Downregulated by CTNNB1 | XM_124474 | -2.60 | |||
| AA058020 | ENOS interacting protein | NM_015953 | -2.11 | |||
| AA031055 | HLA-B-associated transcript 8 (G9a) | XM_128493 | -1.83 | |||
| AA270201 | Hypothetical protein LOC55565 | BC023180 | -1.73 | |||
| AA403866 | Minor histocompatibility antigen H13 isoform 1 | AF483214 | -1.71 | |||
| W99102 | Prion protein | NM_011170 | 3.26 | |||
| AA184845 | Sos homolog 2 | XM_127051 | 2.84 | |||
| AA049482 | EST | AF336797 | 1.87 | |||
| AA166543 | DUTPase | XM_140593 | 1.83 | |||
| AA259502 | EST | N/A | 1.75 | |||
| AA466235 | Inositol 1,3,4-triphosphate 5/6 kinase | XM_127102 | 1.74 | |||
| AA265234 | EST | BC028723 | 1.73 | |||
| AA266813 | Phosphorylase kinase, g2 | XM_133769 | 1.72 | |||
| AA146090 | EST | NM_133362 | 1.71 | |||
| AI508175 | Partitioning defective 3 homolog | XM_134373 | 1.68 | |||
| AA030153 | EST | BC027770 | 1.67 | |||
| W11965 | Enolase 3, b | BC013460 | -2.74 | |||
| AA017876 | EST | N/A | -2.49 | |||
| AA387095 | EST | XM_033377 | -2.45 | |||
| AA242517 | EST | NM_133491 | -2.17 | |||
| AA050726 | Paired mesoderm homeobox 1 | U03873 | -1.96 | |||
| AA003528 | EST | XP_114002 | -1.81 | |||
| AA066202 | Adducin 3g | NM_013758 | -1.71 | |||
| AA176045 | Forkhead box C2 | XM_134407 | -1.70 | |||
| AA547029 | Inhibitor of growth family, member 3 | AY007791 | -1.69 | |||
| W87183 | Small nuclear RNA activating complex, polypeptide 2 | BC011147 | -1.69 | |||
| AA000819 | Sphingosine kinase 1 | XM_126478 | -1.69 | |||
| AA212339 | Ski interacting protein | AK009218 | -1.68 | |||
| AA241295 | Dimethylarginine dimethylaminohydrolase 1 | XM_131205 | -1.67 | |||
| AA208297 | FXYD domain-containing ion transport regulator 2 | NM_052823 | -1.65 | |||
| AA215144 | Neighbor of TID protein 2 | XM_148657 | -1.63 | |||
| W14371 | EST | AL049866 | 2.96 | |||
| AA170654 | EST | AF162137 | 1.69 | |||
| AA541946 | Homolog to DJ453C12.4 (novel protein) | AK005249 | 1.68 | |||
| W14332 | 6-Pyruvoyl-tetrahydropterin synthase | NM_025273 | 1.64 | |||
| AA415819 | Hypothetical protein FLJ13386 | XM_135158 | 1.57 | |||
| AA030609 | Similar to TLM oncogene | AK009671 | -4.47 | |||
| AA060240 | Serine/threonine kinase 39 | NM_016866 | -4.47 | |||
| AA048619 | PES1 protein | AF289539 | -4.01 | |||
| AA274881 | Similar to KIAA1458 protein | XM_132055 | -3.04 | |||
| AA386657 | EST | AF294729 | -2.53 | |||
| AA162920 | Fasting-inducible integral membrane protein | NM_139107 | -2.49 | |||
| AA268977 | Similar to SEC14-like 2 | XM_126025 | -2.42 | |||
| AA058112 | EST | U16028 | -2.36 | |||
| AI552475 | Phospholipase A2-1b gene | AF094611 | -2.33 | |||
| AA059521 | EST | D26607 | -2.31 | |||
| AA125385 | Suppressor of cytokine signaling 3 | AF314501 | -2.25 | |||
| AA266234 | Claudin 7 | BC008104 | -2.14 | |||
| AA015086 | Similar to RNA binding protein | AK008848 | -2.11 | |||
| AA467585 | Homolog to PBK1 protein | AK012937 | -2.07 | |||
| AA016422 | Cerebellin 1 precursor protein | NM_019626 | -2.05 | |||
| AA423248 | EST | BC008069 | -2.01 | |||
| W91197 | EST | XM_085167 | -1.96 | |||
| AA117414 | Hypothetical protein KIAA0759 | XM_132231 | -1.89 | |||
| AA404083 | EST | NM_014915 | -1.65 | |||
| AA437983 | Translocated promoter region protein | AF490392 | -1.64 | |||
| AA098361 | EST | AF143315 | -1.61 | |||
| AA164038 | Axotrophin | NM_020575 | -1.56 | |||
| AA277646 | EST | N/A | -1.54 | |||
| AA118626 |
Hypothetical protein HSPC195 |
XM_087785
|
|
|
|
-1.54 |
Listed are the differential expression ratios of ESTs upregulated and downregulated > 1.5-fold in active caspase 3(+)/TUNEL(-) and active caspase 3(+)/TUNEL(+) neurons from both the pyramidal and granule cell layers when compared with uninjured nonlabeled cells from the identical region. The GenBank accession numbers are listed for the ESTs spotted on the array, in addition to the resulting gene names and accession numbers from the corresponding Basic Local Alignment Search Tool (BLAST) search (as of December 2002).