Figure 10.

Spontaneous and amphetamine-induced activity in CBLG-DT mice. A, Spontaneous activity in an open field was not different between double-transgenic (DT) and wild-type mice. Two-way repeated measures ANOVA revealed a significant effect of time, with the animals being significantly more active during the first 40 min of observation, but there was no genotype effect. B, After injection of amphetamine, there was a significant induction of activity by amphetamine for both groups, as expected (p < 0.001, ANOVA). There was also a genotype effect, with a higher level of induction of activity in the double transgenics during the first 40 min of observation.