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Transgene expression in small striatal neurons in double-transgenic animals. A, Immunoperoxidase staining for β-galactosidase with a Nissl counterstain reveals positive labeling of a number of small striatal neurons. The intense nuclear staining for β-galactosidase is attributable to the incorporation of a nuclear localization signal within the sequence. B, Staining was not observed in large striatal neurons (arrow) or non-neuronal cells (results not shown). Scale bar, 10 μm.
