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. 2004 Mar 24;24(12):3136–3146. doi: 10.1523/JNEUROSCI.4506-03.2004

Figure 7.

Figure 7.

Assessment of striatal measures of dopaminergic innervation in adult CBLG-DT mice. A, Measurement of the optical density of TH-positive fiber immunostaining in striatal coronal sections revealed no differences between double-transgenic (DT) mice and WT and BiTetO-LacZ-rGDNF monotransgenic (MT) controls in adults (n = 3 animals per group, 4–5 sections per animal). B, Western analysis of TH expression in striatal micropunch-dissected tissue revealed no difference between double-transgenic and wild-type mice. C, Stereological assessment of the numbers of DAT-positive punctate structures in complete sets of serial striatal sections using the optical fractionator probe demonstrated no difference between adult double-transgenic and wild-type mice (n = 6, each group). D, Measurement of striatal DA by HPLC revealed no differences between double-transgenic mice and wild-type and monotransgenic controls (G, BiTetO-LacZ-rGDNF monotransgene; CA, CaMKIIα-tTA monotransgene; n = 8, each group).