Table 1.
Morphometric analysis of DA neuron areas and SN volumes in CBLG-DT and WT mice
|
|
PND 7-9 |
Adult |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype |
n
|
Cell area (μm3) |
SN volume (μm3 × 106) |
n
|
Cell area (μm3) |
SN volume (μm3 × 106) |
||||
| WT | 7 | 232 ± 6.3 | 555 ± 33 | 8 | 185 ± 5.4 | 739 ± 25 | ||||
| CBLG-DT |
7 |
370 ± 11.1*
|
616 ± 26 |
8 |
191 ± 5.8 |
778 ± 37 |
||||
At PNDs 7-9, DA neurons were significantly larger in double-transgenic mice. There was no difference in SN volume. In adult animals, there was no difference in either neuron size or SN volume.
*
p < 0.001.