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Camptothecin-induced activation of NF-κB is accompanied by IκB degradation. A, Total cell lysates of cultured cortical neurons at indicated times were analyzed for IκB-α by Western blot analysis. Densitometric analysis of IκB degradation from three independent experiments is provided. All data are normalized to loading controls. Error bars are represented as ±SEM. B, Western blot analyses of cortical neurons for IκB-β levels after camptothecin treatment.
