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Chronic expression of IκBSR results in neuronal death. Embryonic cortical neurons were infected with either GFP or GFP-tagged IκBSR expressing adenoviruses at the time of plating (MOI = 250). At 48, 72, and 96 hr after plating the neuronal cultures were fixed, and GFP-containing neurons were assessed for survival by analyses of nuclear integrity. Each data point is the mean ± SEM of three independent cultures. *p < 0.05 (t test).
