Figure 5.
A, Modulation of GABAA receptor-mediated mIPSCs in CA1 pyramidal neurons in hippocampal slices by the benzodiazepine lorazepam. Data represent the percentage change in mIPSC amplitude at various times during bath application of 3 μm lorazepam for 30 min in the absence or presence of 1 μm finasteride. *p < 0.05 versus control (n = 3-6 cells). B, Normalized average mIPSC traces showing that 3 μm lorazepam during the initial 3 min (time 0) of its bath application increases the current decay time (left), and this effect is not affected by 1 μm finasteride (right). C, Percentage change in mean mIPSC decay time constant τw during the initial 3 min (time 0) of bath application of 3 μm lorazepam in the absence and presence of 1 μm finasteride. *p < 0.05 versus control (n = 3-6 cells).