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. 2004 Sep 8;24(36):7931–7938. doi: 10.1523/JNEUROSCI.2115-04.2004

Figure 4.

Figure 4.

The site of Cl- uptake. A, Optical sectioning by 2P-FLIM extending from the surface of rat olfactory epithelium 10 μm deep into the tissue, recorded with either 50 mm (left stack) or 150 mm (right stack) extracellular Cl-. The white lines follow dendrites through the 2 μm intervals. An increase in [Cl-]i occurs near the apical end of the dendrites in 150 mm extracellular Cl-. B, Axial [Cl-]i profiles in dendrites near the apical surface. With 50 mm extracellular Cl-, [Cl-]i was near 55 mm and no Cl- gradient was established (blue line). At 150 mm extracellular Cl- (red line), a standing [Cl-]i gradient formed between the knobs (70 mm) and the proximal dendrite (55 mm), suggesting that Cl- enters OSNs via the cilia. Means ± SD (7-14 knobs per point).