Skip to main content
. 2004 Sep 8;24(36):7821–7828. doi: 10.1523/JNEUROSCI.1697-04.2004

Figure 4.

Figure 4.

LTP and depotentiation require NR2A-containing NMDARs but not NR2B-containing NMDARs. A, Control experiments (n = 5) showing induction of LTP and depotentiation for interleaved experiments in Figure 4, B and C. B, LTP and depotentiation are not blocked by NR2B antagonist Ro 25-6981 (n = 5). C, LTP and depotentiation are blocked by a selective NR2A antagonist. i, interleaved experiments showing block of LTP using NVP-AAM077 (n = 5). ii, interleaved experiments showing block of depotentiation using NVP-AAM077 (n = 5). D, Selective inhibition of NR2A-containing NMDARs does not prevent LTD in the presence of t-PDC (n = 6).