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. 2004 Oct 6;24(40):8885–8895. doi: 10.1523/JNEUROSCI.2476-04.2004

Figure 7.

Figure 7.

Developmental changes in the synaptic localization of PSD-95 in the VP nucleus of the thalamus. A, B, At P4 (A) and P7 (B), PSD-95 immunogold particles are concentrated at the core of PSD profiles of asymmetrical synapses. Scale bars, 0.1 μm. C, A similar concentration of PSD-95 immunogold particles is consistently found at the core of PSDs of asymmetrical synapses (t) at P32. Scale bar, 0.1 μm. D, Graph showing changes in the mean number of PSD-95 immunogold particles (mean ± SD) at single PSD profiles as a function of postnatal age. Note the dramatic increase in the mean particle number at P4 that remains relatively stable through P32. E, Bar graph showing the distribution of the mean number of PSD-95 immunogold particles at single PSD profiles of thalamic synapses at P32. Note that approximately two to three particles are localized at each single PSD profile (n = 83).