Figure 5.

Percentage of the total contents released during the foot as a function of vesicle radius (calculations for vesicular radii are as described in Materials and Methods). This percentage was obtained by dividing the foot charge by the charge of the total amperometric signal (foot plus spike). The percentage values for each experimental condition examined were then averaged (reserpine, n = 5; control, n = 12; l-DOPA, n = 6); 97, 517, and 182 amperometric spikes were used for each of the points, respectively. By extending the x-axis, the data have been extrapolated to predict that a synaptic vesicle with a radius of 20 nm would release 9% of its total contents through the fusion pore (Δ).