Figure 9.

The distribution of OSNs labeled with OR107 riboprobe is restored after recovery from unilateral MeBr lesion. A, OR107 labeling in lateral cul de sac of a control animal (CI-127). B, C, Corresponding areas of the lateral cul de sac from a unilaterally exposed rat at 3 months after lesion (CI-135) on the closed-naris (unlesioned) and the open-naris (lesioned) sides, respectively. The differences in the labeling patterns between the lesioned side and the same region either on the unlesioned side or in the control epithelium are attributable to the patchy replacement of olfactory by respiratory epithelium as shown by the depletion of OMP staining in that area in a nearby section (data not shown). The regions that have undergone respiratory metaplasia are designated by the lines in the nasal cavity. D is a schematic of the OE illustrating the location of A. E, Schematic of the OE illustrating the location of B and C. Scale bar: (in C) A-C, 100 μm.