Figure 5.

Impaired amygdala LTP by KN-62. A, Schematic of the amygdala slice preparation, showing placement of stimulating and recording electrodes. Recordings were made just below the site of termination of auditory thalamic fibers terminating in the LAd. IC, Internal capsule; OT, optictract; EC, external capsule. B, Mean ± SE percentage EPSP slope (% of baseline) incells (n = 6) before and after treatment with KN-62 (3 μm; solid bar). Traces from an individual experiment before and 25 min after application of KN-62 are shown in the inset. C, Mean ± SE percentage EPSP slope (relative to baseline) in cells treated with vehicle (n = 10; black squares) or 3μm KN-62 (n = 7; black triangles). Traces from an individual experiment before and 50 min after tetanic stimulation are shown in the inset.