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. 2004 Mar 31;24(13):3370–3378. doi: 10.1523/JNEUROSCI.1633-03.2004

Figure 2.

Figure 2.

Aβ-mediated inhibition of LTP induction is prevented by JNK inhibitors. A, LTP induction in JNKI (open circles) and in 500 nm synthetic Aβ plus JNKI (filled circles) was not significantly inhibited. B, LTP induction in naturally secreted cell-derived human Aβ plus JNKI was not significantly inhibited. C, LTP induction in the JNK inhibitor SP600125 (open circles) and in synthetic Aβ plus SP600125 (filled circles) was significantly increased compared with inhibited LTP induction in Aβ. Traces a–c illustrate EPSPs before and 20 and 60 min after HFS, respectively. In A and C, the top set of traces shows the LTP induction in the kinase inhibitor alone, and the bottom set of traces shows the LTP induction in the kinase inhibitor plus Aβ.