Figure 2.

NRG1-erbB signaling and Schwann cell development. During development, neural crest cells give rise to Schwann cell precursors, which then develop into the three adult phenotypes: PSCs, NMSCs, or MSCs. Whereas, during their differentiation into MSCs and NMSCs, the precursors proceed through a stage called immature Schwann cell, the direct precursor of PSCs remains unknown. NRG1-erbB signaling regulates important aspects of Schwann cell biology at each step of their development (see boxed text).