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. 2004 Oct 20;24(42):9405–9413. doi: 10.1523/JNEUROSCI.0899-04.2004

Figure 3.

Figure 3.

Exogenous NT-3 treatment attenuates acid-induced mechanical hyperalgesia. Graph illustrates percentage withdrawal responses to a 1.4 gm monofilament after acid injection in untreated wild-type mice (open circles) compared with mice treated intramuscularly with exogenous NT-3 (black-filled circles), NGF (black-filled squares), or vehicle (saline; open squares). Arrows indicate days on which mice received acid injections into the gastrocnemius. Mice were treated with 1 μg of NT-3 or NGF in 5 μl of saline every other day beginning on the day of the first acid injection. Compared with NGF-treated mice, saline-treated mice, and untreated wild-type mice, NT-3-treated mice show reduced mechanical hyperalgesia 4 d after the second acid injection. NGF had no effect on acid-induced mechanical hyperalgesia. * denotes significant difference between NT-3-treated and nontreated wild-type mice (p < 0.05; ANOVA; Fisher's PLSD). Error bars represent SEM.