Figure 5.

Intramuscular NT-3 treatment is the most effective route of administration. Exogenous NT-3 was administered via different routes: intramuscular, intraperitoneal, or intrathecal. Graph illustrates percentage withdrawal responses to a 1.4 gm monofilament after acid injection. Arrows indicate days on which intramuscular acid injections were administered. Only mice treated with exogenous NT-3 via intramuscular route showed a reduction in mechanical hyperalgesia when compared with mice treated with NT-3 via intraperitoneal and intrathecal routes and mice treated with saline intramuscularly. ^* denotes significant difference between intramuscularly NT-3-treated and saline-treated wild-type mice (p < 0.05; ANOVA; Fisher's PLSD). Error bars represent SEM.