Figure 7.

The neuroprotective actions of NT-3 appear permanent. To determine whether cessation of NT-3 treatment would result in a return to increased paw sensitivity, NT-3 treatment was stopped from day 11 onwards (indicated by upward arrow) in mice that were treated with NT-3 (i.m.) beginning on the first day of acid injection. Graph illustrates percentage withdrawal responses to a 1.4 gm monofilament after acid injection. Downward arrows indicate days on which intramuscular acid injections were administered. After cessation of NT-3 treatment, mice continued to exhibit reduced mechanical hyperalgesia after treatment of NT-3 compared with saline-treated mice. ^* denotes significant differences between NT-3-treated and saline-treated mice (p < 0.05; ANOVA; Fisher's PLSD). Error bars represent SEM.