Table 1.

Thermal Iatencies to radiant heat

	Ipsilateral paw	Contralateral paw
NT-3 overexpression
Wild type	6.07 ± 0.58	7.39 ± 0.71
Low-OE myo/NT-3	7.35 ± 0.73	9.93 ± 1.1
High-OE myo/NT-3	7.12 ± 0.70	8.75 ± 1.3
Exogenous NT-3 treatment
WT—no acid, untreated	4.43 ± 0.40	4.51 ± 0.25
WT—saline treated (i.m.)	5.01 ± 0.32	5.11 ± 0.41
WT—NT-3 treated (i.m.)	4.45 ± 0.29	5.22 ± 0.57
Routes of administration
WT—NT-3 treated (i.m.)	3.96 ± 0.76	3.41 ± 0.58
WT—NT-3 treated (i.p.)	3.40 ± 0.63	4.01 ± 0.46
WT—NT-3 treated (i.t.)	4.00 ± 0.56	3.97 ± 0.68

Four weeks after acid injection, thermal responses were recorded from each paw as withdrawal latencies from a radiant heat source (seconds). In regard to NT-3 overexpression, wild-type (WT) mice were derived from litters within the myo/NT-3 colony. For exogenous treatments, wild-type CF-1 mice were purchased from Charles River. Comparisons were made between test groups using one-way ANOVA and Fisher's PLSD. No differences in thermal thresholds were observed among transgenic or NT-3-treated mice or by using different routes of NT-3 administration (p > 0.05). Data are plotted as means ± SEM.