Table 3.
Effects of administration twice daily of escalating doses of morphine for 8 consecutive days during early (12 hr) and late (8 d) withdrawal on CRF mRNA expression in various nuclei in the brain
|
|
12 hr withdrawal |
8 d withdrawal |
||||
|---|---|---|---|---|---|---|
|
|
Vehicle |
Morphine |
Vehicle |
Morphine |
||
| CRF | ||||||
| Amygdala | 97 ± 7 | 72 ± 8** | 91 ± 11 | 142 ± 25* | ||
| Barrington's nucleus | 99 ± 5 | 119 ± 8** | 115 ± 12 | 186 ± 25** | ||
| BNST oval | 107 ± 12 | 169 ± 13*** | 97 ± 6 | 93 ± 7 | ||
| BNST fusiform |
91 ± 8 |
144 ± 16**
|
106 ± 7 |
99 ± 7 |
||
Data are expressed as a percentage of vehicle control. Values represent the mean ± SEM of eight rats per group. Vehicle versus morphine treated: *0.1<p< 0.05; **p<0.05; ***p<0.01.