Table 4.
Effects of administration twice daily of escalating doses of morphine for 8 consecutive days during early (12 hr) and late (8 d) withdrawal on NPY and POMC mRNA expression in the arcuate nucleus of the hypothalamus
|
|
12 h withdrawal |
8 d withdrawal |
||||
|---|---|---|---|---|---|---|
|
|
Vehicle |
Morphine |
Vehicle |
Morphine |
||
| NPY | ||||||
| Anterior ARC | 98 ± 5 | 73 ± 9* | 102 ± 8 | 134 ± 8* | ||
| Medial ARC | 103 ± 11 | 122 ± 18 | 96 ± 11 | 105 ± 13 | ||
| Posterior ARC | 109 ± 13 | 115 ± 11 | 101 ± 10 | 107 ± 10 | ||
| POMC | ||||||
| Anterior ARC | 90 ± 7 | 96 ± 9 | 109 ± 14 | 121 ± 8 | ||
| Medial ARC | 109 ± 10 | 110 ± 15 | 106 ± 9 | 107 ± 7 | ||
| Posterior ARC |
96 ± 6 |
103 ± 14 |
91 ± 8 |
105 ± 9 |
||
Data are expressed as a percentage of vehicle control. Values represent the mean ± SEM of eight rats per group. Vehicle versus morphine treated, *p < 0.05.