Table 1.

Effect of CNP and KT5823 on cocaine-induced egr-1 expression

	Dor CPu	Lat CPu	NAc	CgCx
Cocaine	5.8 ± 0.9	6.0 ± 1.4	10.7 ± 0.9	5.3 ± 1.3
Cocaine plus CNP	2.4 ± 0.8***	2.2 ± 0.9***	7.1 ± 0.6***	7.4 ± 0.7*
Cocaine plus CNP plus KT5823	6.2 ± 1.2###	6.5 ± 0.7###	8.5 ± 1.0#	6.2 ± 1.1

Data show Egr-1 mRNA expression in comparable areas of the NAc shell, the dorsal (Dor CPu) or lateral (Lat CPu) region of the striatum, and the anterior CgCx from rats given microinjections of 2 nmol of CNP, 2 nmol of KT5823, or vehicle into the hemi-CPu. Fifteen minutes later, rats were given intraperitoneal injections of cocaine (20 mg/kg) and killed 45 min afterward. The results are expressed as kilobecquerels per gram of tissue, as means ± SD (n = 12 sections from 3 animals). ^* or ^#p < 0.05 and ^*** or ^###p < 0.001. Asterisks indicate significance levels when comparing CNP versus the vehicle group; ^# indicates significance when comparing CNP plus KT5823 versus CNP treatment (ANOVA, followed by Student-Newman-Keuls multiple comparisons test).