. 2004 Oct 27;24(43):9632–9637. doi: 10.1523/JNEUROSCI.2236-04.2004

Table 2.

Effects of inhibitors for IDE on the elimination rate of [¹²⁵I]Aβ(1-40) from rat brain

Inhibitor	Apparent elimination rate constant (k_app,el) (percentage of control)
Control	100.0 ± 6.8
Bacitracin (1 mg/ml)	76.7 ± 8.9
N-ethylmaleimide (1 mm)	106.8 ± 5.5
Control (PBS)^a	100.0 ± 7.1
1, 10-Phenanthroline (1 mm)^a	99.4 ± 15.4
EDTA (5 mm)^a	98.1 ± 12.8

Bacitracin, N-ethylmaleimide, 1, 10-phenanthroline, and EDTA were each preadministered before [¹²⁵I]Aβ(1-40) and [¹⁴C]inulin administration. The clearance was evaluated as k_app,el. Each value represents the mean ± SEM (n = 3).

The elimination rate was examined in the presence of 1, 10-phenanthroline or EDTA dissolved in PBS.