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. 2004 Nov 10;24(45):10074–10083. doi: 10.1523/JNEUROSCI.2604-04.2004

Figure 1.

Figure 1.

Structure of transgenes and characterization of transgenic mice. A, Partial structure of GFAP/tTA and TRE/IFN-γ transgenes. B, Cerebellar LacZ staining of P12 GFAP/tTA;TRE/LacZ double transgenic mice released from doxycycline at E16. Inset, The differential interference contrast photograph shows LacZ-positive cells are not Purkinje cells (arrows). C, Forebrain LacZ staining of P12 GFAP/tTA;TRE/LacZ double transgenic mice released from doxycycline at E16. D, Spinal cord LacZ staining of P12 GFAP/tTA;TRE/LacZ double transgenic mice released from doxycycline at E16. E, Cerebellar LacZ staining of P18 GFAP/tTA;TRE/LacZ double transgenic mice released from doxycycline at E16, then retreated with doxycycline at P12. F, Cerebellar LacZ staining of 5-week-old GFAP/tTA;TRE/LacZ double transgenic mice on doxycycline until 3 weeks of age and then released from doxycycline to induce LacZ expression. Scale bars: B-D, 50 μm; E, F, 200 μm.