Figure 2.
Ionic specificity and pharmacological block of the proton-elicited responses in SG neurons. A, Comparison of inward currents recorded when Na+ ions were substituted by choline+ in the external (Ext.) solution. pH values and approximate duration of perfusions are given by the numbers and horizontal bars above the data traces. B, Inhibitory dose-response of amiloride. Black dots and error bars give the average data and SEMs, respectively. The smooth curve was obtained by fitting the data with the following equation: %response = (1 - [amiloride]n/(IC50n + [amiloride]n)) × 100, in which IC50 is the half-maximal inhibition concentration of amiloride, and n is the coefficient factor. Inset, One example of the pH 4.5-elicited currents blocked by 50 μm amiloride.