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. 2004 Nov 10;24(45):10167–10175. doi: 10.1523/JNEUROSCI.3196-04.2004

Figure 3.

Figure 3.

Comparison of proton-elicited responses obtained from wild-type and ASIC2 knock-out mice. Inward currents elicited by increasing concentrations of protons in the wild-type (A) and ASIC2 KO (B) mice. pH values and the approximate duration of the external solution applied are indicated by numbers and black bars above the data traces, respectively. Time and amplitude scales are the same for both A and B. C, Ionic fluxes elicited by protons obtained in ASIC2 knock-out mice normalized to that of the wild-type mice. Total ionic fluxes were obtained by integrating inward currents induced by protons. The x-axis gives the pH value of external solutions applied to the SG neurons. Error bars indicate SEM. D, α-DTX (top data trace) and proton-elicited (bottom data trace) voltage responses obtained from the same SG neurons under current clamp. The average resting membrane potential of the SG neuron was approximately -63 mV. The approximate duration of the applications of α-DTX and proton are indicated by horizontal bars under the data traces.