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. 2004 Dec 1;24(48):10816–10825. doi: 10.1523/JNEUROSCI.2931-04.2004

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Copyright © 2004 Society for Neuroscience 0270-6474/04/2410816-10.00/0

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Figure 8. — PAK3 MRX30 mutation is associated with altered postsynaptic properties and defects in synaptic plasticity. A, Paired-pulse facilitation does not differ between control (Ctrl) and PAK3 MRX30-transfected cells (n = 6). B, Illustration of AMPA and NMDA EPSCs evoked by the same stimulation pulses in control and PAK3 MRX30-transfected cells. C, Quantitative assessment of AMPA/NMDA ratio measured in six control (gray column) and six PAK3 MRX30-transfected (black column) neurons. ^*p < 0.05. D, PAK3 MRX30-transfected cells show alterations of synaptic plasticity. Changes in EPSP slope induced by a pairing protocol in five control and seven PAK3 MRX30-transfected neurons. Data are mean ± SEM. Differences are statistically significant (p < 0.01).