Figure 3.

The cortical phenotype of p73^-/- mice. A, B, P12 mice, Nissl stain. The frontal (motor) cortex of p73^+/- mice (A) displays normal cytoarchitecture. In the p73^-/- motor cortex (B), basic lamination and cytoarchitecture are preserved, but the cortex is smaller and white matter (wm) is reduced. C, D, p73^-/- (same case as in B), stained with Nissl (C) and Reelin (D). In occipital cortex, lamination is lost and cell density is reduced. Irregular clusters of Reelin-IR neurons are present in the profoundly altered cortex. Scale bars: A, B, 200 μm; C, D, 100 μm.