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. 2004 Nov 3;24(44):9953–9961. doi: 10.1523/JNEUROSCI.2134-04.2004

Figure 2.

Figure 2.

Induction of LTDi involves activation of group I mGluRs. A, The unselective group I mGluR agonist DHPG (50 μm) leads to a long-lasting suppression of GABAergic currents similar to LTDi in wild-type mice (CB1+/+; effect of DHPG, 72 ± 5% of control; n = 8; p < 0.05; •) but not in mice lacking CB1 receptors (CB1-/-; effect of DHPG, 101 ± 3%; n = 5; p > 0.05; ○). B, Application of DHPG (50 μm) occludes the induction of LTDi by LFSi (effect of LFSi in the presence of DHPG, 106 ± 13% of control; n = 6; p > 0.05). LTDi without DHPG (data from Fig. 1 A) is shown for comparison (squares). C, The transient application of DHPG (50 μm) also induces a long-lasting decrease of the IPSC amplitude to 64 ± 3% (n = 8; p < 0.05). D, This effect of DHPG is occluded by a preceding induction of LTDi (control, 100%; LFSi, 66 ± 8%; n = 5; p < 0.05; DHPG, 75 ± 4%; n = 5; p > 0.05). Representative traces of IPSCs are shown. The experiments depicted in B-D were performed in C57BL/6JOlaHsd mice.