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. 2004 Nov 17;24(46):10511–10520. doi: 10.1523/JNEUROSCI.2828-04.2004

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Copyright © 2004 Society for Neuroscience 0270-6474/04/2410511-10.00/0

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Figure 7. — Intrathecal NgR(310)ecto-Fc improves behavioral recovery after rat dorsal over-hemisection. A-C, The locomotor BBB score is reported as a function of time after dorsal over-hemisection in the vehicle- or NgR(310)ecto-Fc-treated rats from three separate experiments. For the specific rats in which tissue sparing was measured in Figure 3B, the results were indistinguishable in A. For example, the 21 d BBB control score was 12.5 ± 0.9, and the NgR(310)ecto-Fc score was 15.5 ± 0.2 (p < 0.01). Experiment A (n = 7-9 rats per group) was performed at Yale University, experiment B was performed at BiogenIdec (n = 25-26 rats per group), and experiment C was performed at Yale University (n = 8-9 rats per group). D, Examples of the representative footprints from one control (top) or two NgR(310)ecto-Fc-treated (bottom) rats 4 weeks after the dorsal over-hemisection. E, Footprint analysis reveals a shorter stride length and a greater stride width in control rats (n = 7 rats) than in uninjured (n = 6 rats) or injured/NgR(310)ecto-Fc (n = 9 rats) rats. F, Hindlimb errors during grid walking are reported as a function of post-SCI time in the control (n = 7 rats) or NgR(310)ecto-Fc-treated (n = 9 rats) groups. G, BBB score is plotted as a function of time after the dorsal over-hemisection in the animals receiving intracerebroventricular serotonin neurotoxin DHT injection 3 weeks after SCI (n = 9 rats in each group). Notably, the locomotor BBB score in NgR(310)ecto-Fc-treated rats 3 weeks after SCI was significantly decreased after DHT administration. H, The maximal tolerated inclined plane angle is reported as a function of time after SCI from these rats receiving intracerebroventricular DHT injections (n = 9 rats in each group). The inclined plane angle in NgR(310)ecto-Fc-treated rats was significantly decreased at 4 weeks after injury because of DHT application. Means + SEM are reported in all the graphs. The values of NgR(310)ecto-Fc group are statistically different from control as indicated in A and F-H. The control IgG treatment values are statistically different from no-SCI or SCI plus NgR(310)ecto-Fc rats in E. In G and H, the 28 and 35 d values for the NgR(310)ecto-Fc-treated rats were significantly different from the same animals at day 21 before DHT. (^*p < 0.05; ^**p < 0.01; Student's t test).