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D2 receptor activation reduced persistent Na+ currents. A, Current-voltage plot of TTX-sensitive persistent Na+ currents evoked by a slow voltage ramp (4 sec) from -80 to 0 mV in an acutely isolated cholinergic interneuron. B, NPA (10 μm) reversibly reduced persistent Na+ currents. The current-voltage relationship of the TTX-sensitive currents before and after NPA application. C, Conversion of the current-voltage plots in A to conductance estimates were fit using an HH model.
