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Scheme to illustrate the proposed mechanism for C5-gephyrin-dependent control of GlyR anchoring. A, Postsynaptic lattice containing a variable amount of C5-gephyrin trimers (black). The highest amount is present in purely GABAergic synapses. The suppression of GlyR accumulation may either be limited to the C5-gephyrin sites (B) or additionally involve the area occupied by neighboring C5-lacking gephyrins, provided the latter are also under the influence of C5-gephyrins.
