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. 2004 Dec 15;24(50):11449–11456. doi: 10.1523/JNEUROSCI.3597-04.2004

Figure 4.

Figure 4.

The effects of the intranigral perfusion of the GABA-A receptor antagonist BIC (10 μm) on METH-induced changes in extracellular GABA in the VM thalamus. Four injections of METH (10 mg/kg) or 0.9% saline (1 ml/kg) were given every 2 hr (indicated by arrows). Dialysate samples were collected in the VM every hour during the 2 hr baseline period and the 8 hr drug treatment period. BIC was reverse dialyzed into the SNr after the baseline period and continuously perfused until the end of the experiment (indicated by hatched bar). Data are expressed as mean ± SEM percentage of baseline values. METH plus vehicle group showed a significant decrease in extracellular GABA concentrations compared with METH plus BIC (two-way ANOVA with repeated measures, BIC main effect; F(1,379) = 15.34; p < 0.05). There was no difference between saline plus vehicle-, saline plus BIC-, and METH plus BIC-treated rats. n = 9-10 rats per group.