Table 1.

Desensitization time constants

Receptor	Residues exchanged	τDES (msec)
GluR1i	-	3.8 ± 0.05 (12)
GluR1o	-	4.2 ± 0.2 (10)
GluR2i	-	5.8 ± 0.2 (20)
GluR2o	-	1.6 ± 0.1 (16)
GluR3i	-	3.6 ± 0.3 (10)
GluR3o	-	1.5 ± 0.1 (7)
GluR4i	-	5.1 ± 0.4 (16)
GluR4o	-	0.9 ± 0.03 (14)
GluR2io,i,i	T765N, P766A	2.7 ± 0.1 (15)
GluR2ii,o,i	S775N	4.7 ± 0.2 (16)
GluR2iV779L	V779L	5.1 ± 0.2 (13)
GluR2ii,i,o	A796S, K797G, D798G, S799G, G800D	5.8 ± 0.2 (23)
GluR2io,o,i	T765N, P766A, S775N	1.8 ± 0.1 (18)
GluR2iT765N	T765N	3.6 ± 0.1 (18)
GluR2iP766A	P766A	3.6 ± 0.2 (15)
GluR2io,i,o	T765N, P766A, K797G, D798G, S799G, G800D	2.5 ± 0.1 (18)
GluR2io,i,V779L,i	T765N, P766A, V779L	2.1 ± 0.2 (15)
GluR2oi,o,o	N765T, A766P	4.2 ± 0.2 (15)
GluR2oo,i,o	N775S	2.3 ± 0.1 (13)
GluR2oi,i,o	N765T, A766P, N775S	5.7 ± 0.2 (20)

τ_DES was estimated from single exponential fits as described in Materials and Methods. Numbers in parentheses indicate the number of cells.