Figure 1.

a, Genomic screening strategy with a CpG island library. The plasmid DNA was bound with GST-DRG11-DBD and passed through a nitrocellulose filter. DRG11-bound plasmids were eluted and amplified in bacterial cultures. The DRG11-bound plasmids were concentrated over three cycles. b, Full coding cDNA sequence of DRAGON with its open reading frame and putative protein sequence. DRAGON protein has an N-terminal signal peptide and a C-terminal GPI anchor but no other highly conserved domains. c, Top, Schematic representation of the DRAGON gene with its promoter region and three exons. Bottom, DRAGON protein structure with its N-terminal signal peptide andC-terminal GPI anchor.