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. 2004 Feb 25;24(8):1865–1872. doi: 10.1523/JNEUROSCI.3309-03.2004

Figure 4.

Figure 4.

Effects of caspase-11 ablation on MPTP-induced neuronal cell death. A-H, TH and Nissl double staining in the SN 7 d after the last saline injection in wild-type (A) and caspase-11-/- (B) mice, 7 d after the last acute MPTP injection in wild-type (C, G) and caspase-11-/- (D, H) mice, and 21 d after the last chronic MPTP injection in wild-type (E) and caspase-11-/- (F) mice. G, H, Higher magnification of C and D, respectively. Scale bars, 100 μm. I, For all animals, the striatum was dissected for measurement of dopamine and DOPAC 7 d after the last administration of acute MPTP treatment between wild-type (□) and caspase-11-/- (▪) mice. Data are means ± SEM of five mice per group. *p < 0.01; Scheffé's test.