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. 2004 Mar 3;24(9):2322–2327. doi: 10.1523/JNEUROSCI.4675-03.2004

Figure 2.

Figure 2.

PRO enhances the maximal responses of wt and hyperekplexic α1 GlyRs to partial agonists. A, β-Alanine and glycine-induced responses recorded from oocytes expressing α1(R271K) GlyRs in the absence (-PRO) or presence (+PRO) of bath-applied PRO (0.5 mm). Bars indicate the duration of agonist application; agonist concentrations are given in mm. B, Pooled dose-response curves for β-alanine for α1 wt (circles) and α1(R271K) (squares) GlyRs in the absence (open symbols) and presence (filled symbols) of 0.5 mm PRO, respectively. Data are normalized to Imax,Gly obtained with saturating glycine concentrations (n = 5).